Phenotypes associated with this allele

• Allele Symbol: Arhgef11^tm1.1Mak
• Allele Name: targeted mutation 1.1, Tak Mak
• Allele ID: MGI:5788572
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef11^tm1.1Mak/Arhgef11^tm1.1Mak	B6.129P2(C)-Arhgef11^tm1.1Mak	MGI:5796175

Genotype
MGI:5796175

hm1

• Allelic Composition: Arhgef11^tm1.1Mak/Arhgef11^tm1.1Mak
• Genetic Background: B6.129P2(C)-Arhgef11^tm1.1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal white fat cell differentation ( J:233950 )

• reduced numbers of adipogenic progenitor and preadipocyte populations

• adipose tissue stromal cells differentiate into mature adipocytes at a lower rate than controls

• cultured adipogenic progenitors from epidermal WAT have a reduced proliferative capacity as measured by BrdU incorporation

decreased white fat cell number ( J:233950 )

• decreased number of mature adipocytes in epidermal white adipose tissue

decreased percent body fat/body weight ( J:233950 )

• decreased body fat index as compared to wild-type

decreased white adipose tissue mass ( J:233950 )

• reduction in white adipose tissue mass both as total mass and a percentage of body weight

• Fat pads from epidermal (EWAT), knee (KWAT), inguinal (IWAT) and retoperitoneal (RWAT) white adipose tissue are smaller as compared to controls

• brown adipose tissue is not significantly affected

abnormal white adipose tissue physiology ( J:233950 )

• cultured adipogenic progenitors from epidermal WAT have a reduced proliferative capacity as measured by BrdU incorporation

• MEFs exhibit impaired cell proliferation under normal growth conditions and in response to fetal calf serum

• higher extracellular acidification (glycolysis) rate is observed in epidermal WAT

• increase in total oxygen consumption in epidermal WAT as compared to wild-type

behavior/neurological

hyperactivity ( J:233950 )

• mice exhibit higher total activity

increased stereotypic behavior ( J:233950 )

cellular

abnormal white fat cell differentation ( J:233950 )

• reduced numbers of adipogenic progenitor and preadipocyte populations

• adipose tissue stromal cells differentiate into mature adipocytes at a lower rate than controls

• cultured adipogenic progenitors from epidermal WAT have a reduced proliferative capacity as measured by BrdU incorporation

growth/size/body

decreased body weight ( J:233950 )

• decreased body weight beginning at 8 weeks of age on normal chow diet

• no difference in body length or food consumption is observed

decreased susceptibility to diet-induced obesity ( J:233950 )

• mice gain less weigh and have less adiposity than wild-type on high fat diet despite eating the same amount of food

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:233950 )

• mice gain less weigh and have less adiposity than wild-type on high fat diet despite eating the same amount of food

increased oxygen consumption ( J:233950 )

• increase in total oxygen consumption in epidermal WAT as compared to wild-type

increased respiratory quotient ( J:233950 )

• respiratory exchange rate from epidermal WAT is higher than controls, especially at the end of the light cycle

abnormal glucose homeostasis ( J:233950 )

• higher extracellular acidification (glycolysis) rate is observed in epidermal WAT

decreased susceptibility to diet-induced non-insulin dependent diabetes ( J:233950 )

• mice gain less weight, maintain normal glucose homeostasis and have less adiposity than wild-type on high fat diet

• mice do not develop glucose intolerance, insulin resistance, fatty liver, inflammation or adipocyte hypertrophy