Relbtm1Ukl
Targeted Allele Detail
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Symbol: |
Relbtm1Ukl |
Name: |
avian reticuloendotheliosis viral (v-rel) oncogene related B; targeted mutation 1, Ulf Klein |
MGI ID: |
MGI:5788155 |
Synonyms: |
relbfl |
Gene: |
Relb Location: Chr7:19340142-19363352 bp, - strand Genetic Position: Chr7, 9.93 cM
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Alliance: |
Relbtm1Ukl page
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Allele Type: |
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Targeted (Conditional ready, No functional change, Reporter) |
Mutation: |
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Insertion
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Mutation details: Sequence encoding a promoterless eGFP minigene, a loxP site and the PGKneo cassette is inserted upstream of exon 1 (containing the translation start site), and another loxP site followed by the PGK promoter is inserted downstream of exon 2. The entire targeted region is flanked by FRT sites. Recombination using Cre recombinase will remove the exons while allowing EGFP expression or FLP-mediated recombination will remove both the exons and the EGFP.
(J:233743)
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Original: |
J:233743 De Silva NS, et al., Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-kappaB Transcription Factors RELB and NF-kappaB2 in B Cells. J Immunol. 2016 Mar 15;196(6):2591-601 |
All: |
10 reference(s) |
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