Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ap1g1fgt
Name:	adaptor protein complex AP-1, gamma 1 subunit; figure eight
MGI ID:	MGI:5755140
Gene:	Ap1g1  Location: Chr8:110505215-110590842 bp, + strand  Genetic Position: Chr8, 57.26 cM
Alliance:	Ap1g1fgt page

Strain of Origin:

C57BL/6-Tg(APOA1)1Rub/J

Allele Type:    Spontaneous (Hypomorph) Mutation:    Intragenic deletion   Mutation details: This spontaneous 6 bp deletion of TTTCTG in exon 13 of NM009677, isoform 1, and exon 12 of Nm002301211, isoform 2, is predicted to cause an in-frame deletion of F391 and L392 of isoform 1, or F388 and L389 of isoform 2, amino acids which are in the adaptin N-terminal homology domain involved in interactions with other subunitos of the AP-1 complex. (J:230572) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ap1g1 Mutation:	46 strains or lines available

Original:	J:230572 Johnson KR, et al., A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice. Mamm Genome. 2016 Jun;27(5-6):200-12
All:	1 reference(s)