Chn1tm3.2Ito
Targeted Allele Detail
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Symbol: |
Chn1tm3.2Ito |
Name: |
chimerin 1; targeted mutation 3.2, Shigeyoshi Itohara |
MGI ID: |
MGI:5754367 |
Synonyms: |
Chn1alpha1KO |
Gene: |
Chn1 Location: Chr2:73441004-73605690 bp, - strand Genetic Position: Chr2, 43.78 cM
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Alliance: |
Chn1tm3.2Ito page
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Germline Transmission: |
Earliest citation of germline transmission:
J:229380
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Parent Cell Line: |
MS12 (ES Cell)
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Strain of Origin: |
C57BL/6NSlc
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Allele Type: |
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Targeted (Modified isoform(s)) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upsteam of exon 7. An additional loxP site was inserted into the untranslated region of exon 7. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the untranslated region in exon 7. Western blot analysis confirmed the absence of alpha1 isoform expression but continued expression of isoform alpha2 in the hippocampus.
(J:229380)
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Original: |
J:229380 Iwata R, et al., RacGAP alpha2-chimaerin function in development adjusts cognitive ability in adulthood. Cell Rep. 2014 Sep 11;8(5):1257-64 |
All: |
1 reference(s) |
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