Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Akap11tm1.2Jsco
Name:	A kinase anchor protein 11; targeted mutation 1.2, John D Scott
MGI ID:	MGI:5751858
Synonyms:	AKAP220-KO
Gene:	Akap11  Location: Chr14:78729686-78774248 bp, - strand  Genetic Position: Chr14, 41.46 cM
Alliance:	Akap11tm1.2Jsco page

Germline Transmission:	Earliest citation of germline transmission: J:234905
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A loxP site and FRT-flanked neomycin cassette are introduced into intron 5 followed by a loxP site placed in intron 7. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed exons 6 and 7. Western blot anaylsis on nine tissues confirmed that no protein was expressed in mutant mice. (J:234905)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akap11 Mutation:	65 strains or lines available

Original:	J:234905 Whiting JL, et al., AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4328-37
All:	4 reference(s)