Phenotypes associated with this allele

• Allele Symbol: Akap11^tm1.2Jsco
• Allele Name: targeted mutation 1.2, John D Scott
• Allele ID: MGI:5751858
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akap11^tm1.2Jsco/Akap11^tm1.2Jsco	B6.Cg-Akap11^tm1.2Jsco	MGI:5793068

Genotype
MGI:5793068

hm1

• Allelic Composition: Akap11^tm1.2Jsco/Akap11^tm1.2Jsco
• Genetic Background: B6.Cg-Akap11^tm1.2Jsco

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:234905 )

• mice decrease amount of time in open central zone of open field test

• increased number of fecal boluses in open field test, an index of anxiety

increased thigmotaxis ( J:234905 )

decreased locomotor activity ( J:234905 )

• decrease in total distance traveled in open field test as compared to controls

slow movement ( J:234905 )

• decrease in average velocity compared to controls

growth/size/body

decreased body size ( J:234905 )

• decreased body size as compared to controls

• however, feeding behavior is normal

decreased body weight ( J:234905 )

• total body weight is reduced in males and females

• reduced weight is observed before weaning and continues through adulthood

• no differences are observed in organ weights

decreased body length ( J:234905 )

homeostasis/metabolism

increased urine osmolality ( J:234905 )

• urine osmality is 1.75 fold higher in water-loaded mutants as compared to water-loaded controls

limbs/digits/tail

short tibia ( J:234905 )

renal/urinary system

increased urine osmolality ( J:234905 )

• urine osmality is 1.75 fold higher in water-loaded mutants as compared to water-loaded controls

abnormal kidney collecting duct morphology ( J:234905 )

• apical actin network is reduced in kidney-collecting duct cells following over hydration

• 30.8% reduction in actin barrier density

skeleton

short tibia ( J:234905 )