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Gene Expression Data
Assay Details
Assay
Reference: J:204675 Mandal S, et al., Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons. J Neurosci. 2013 Oct 23;33(43):16897-914
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5702489
Gene symbol: Calb1
Gene name: calbindin 1
Antibody: anti-calbindin
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 8A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cerebral cortex Present 8A

Specimen 8A': embryonic day 15.5; Gucy1a1tm1.1Brou/Gucy1a1tm1.1Brou (more )
Structure Level Pattern Image Note
TS23: cerebral cortex Present 8A' About 50% reduction in the number of positive interneurons.
TS23: cerebral cortex subventricular zone Present 8A' About 50% reduction in the number of positive interneurons.
TS23: cortical plate Present 8A' About 50% reduction in the number of positive interneurons.

Specimen 8B: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cerebral cortex Present 8B

Specimen 8B': embryonic day 15.5; Gucy1a1tm1.1Brou/Gucy1a1tm1.1Brou (more )
Structure Level Pattern Image Note
TS23: cerebral cortex Present 8B' About 50% reduction in the number of positive interneurons.
TS23: cerebral cortex subventricular zone Present 8B' About 50% reduction in the number of positive interneurons.
TS23: cortical plate Present 8B' About 50% reduction in the number of positive interneurons.

Specimen 8C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cerebral cortex Present 8C

Specimen 8C': embryonic day 15.5; Gucy1a1tm1.1Brou/Gucy1a1tm1.1Brou (more )
Structure Level Pattern Image Note
TS23: cerebral cortex Present 8C' About 50% reduction in the number of positive interneurons.
TS23: cerebral cortex subventricular zone Present 8C' About 50% reduction in the number of positive interneurons.
TS23: cortical plate Present 8C' About 50% reduction in the number of positive interneurons.

Specimen not shown: embryonic day 13.5; Gucy1a1tm1.1Brou/Gucy1a1tm1.1Brou (more )
Structure Level Pattern Image Note
TS21: medial ganglionic eminence Present Expressed in interneurons migrating from the medial ganglionic eminence. No neurite or migration deficits were seen.

Specimen not shown: postnatal day 0; Gucy1a1tm1.1Brou/Gucy1a1tm1.1Brou (more )
Structure Level Pattern Image Note
TS27: cortical plate Present Regionally restricted A subtle reduction in positive interneurons in the rostral cortical plate.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/24/2026
MGI 6.24
The Jackson Laboratory