Summary | Transgene origin | Transgene description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(EIF1AX-Aldh2*E487K)101Oht
Name:	transgene insertion 101, Shigeo Ohta
MGI ID:	MGI:5699091
Synonyms:	DAL101
Transgene:	Tg(EIF1AX-Aldh2*E487K)101Oht  Location: unknown
Alliance:	Tg(EIF1AX-Aldh2*E487K)101Oht page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Dominant negative, Inserted expressed sequence) Mutation:    Single point mutation   Tg(EIF1AX-Aldh2*E487K)101Oht expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Aldh2 (MGI:99600)   Mutation details: The murine gene with a single point mutation of G to A in exon 12 that is confined to Asians and results in a substitution of glutamine 487 to lysine (E487K) is under the control of the human elongation factor-1 alpha. This mutation results in a dominant-negative effect. Three lines were established: DAL101, DAL102, and DAL103. DAL101 is the high expressing line. (J:137374)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:137374 Ohsawa I, et al., Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci. 2008 Jun 11;28(24):6239-49
All:	3 reference(s)