Analysis Tools
behavior/neurological
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• 6 month old mutants are unable to learn the Morris water maze task and the time spent in the target quadrant during probe trials is shorter than in either single mutant
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Allele Symbol Allele Name Allele ID |
Tg(EIF1AX-Aldh2*E487K)101Oht transgene insertion 101, Shigeo Ohta MGI:5699091 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 6 month old mutants are unable to learn the Morris water maze task and the time spent in the target quadrant during probe trials is shorter than in either single mutant
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants begin dying by 120 days of age and death rate accelerates after 240 days compared to either single mutant
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• mutants weigh less than wild-type mice and single Tg(EIF1AX-Aldh2*E487K)101Oht mice, but exhibit no weight differences from single Tg(APPSWE)2576Kha mice
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• in the object recognition test, exploratory preference for the novel object is lower at 3 months of age compared to wild-type mice or either single mutant, and is lower at 6 months of age compared to wild-type mice or single Tg(EIF1AX-Aldh2*E487K)101Oht mice
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• at 3 and 6 months of age, the alternation rate of Y-maze is lower than in wild-type mice or either single mutant
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• amyloid beta plaques are detected in the brain at 6 months of age, a time when plaques are not seen in single Tg(APPSWE)2576Kha mice
• at 12-15 months of age, more amyloid beta40 and amyloid beta42 plaques are seen than in single Tg(APPSWE)2576Kha mice
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• amyloid beta plaques are detected in the brain at 6 months of age, a time when plaques are not seen in single Tg(APPSWE)2576Kha mice
• at 12-15 months of age, more amyloid beta40 and amyloid beta42 plaques are seen than in single Tg(APPSWE)2576Kha mice
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• deposition of phosphorylated tau proteins in the brains is increased at 9 months of age compared to single Tg(APPSWE)2576Kha mice
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• mutants show a greater number of astrocyte clusters in the CA1 region of the hippocampus and cerebral cortex at 6, 9, and 12 months of age than single Tg(APPSWE)2576Kha mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:219346 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• median lifespan is 96 weeks compared to 126 weeks for controls, with maximal lifespan at 129 weeks compared to 153 weeks for controls
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• aged (11-14 months), but not young (6-8 months) males show impaired visual recognition memory, with mice not approaching or sniffing a novel object more times than the original object as seen in controls and young mice
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• in the Morris water maze, 1 and 1.5 year old females are able to learn the task but they require 5 days training to reach criterion compared to 3 days in controls and they spend less time in the target quadrant during proble trials
• however, females at 6 months of age have intact spatial learning and memory and no deficits in probe trials in the Morris water maze
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• some hair decolorization is seen in one year old males
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• one year old males show muscle weakness
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• increase in hyperphosphorylated tau in the hippocampus of 1 and 1.5 year old mice
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• degeneration and decrease in pyramidal neurons in the CA1 region of the hippocampus
• 20% and 77.8% of mice show neurodegeneration at 1 year and 1.5 years of age, respectively
• neurons are decreased in the in the hilus of the dentate gyrus of aged mice
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• increase in activated astrocytes is seen in the hippocampus of old mice, with 60% and 55.6% of mice showing activation of astrocytes at 1 and 1.5 years of age, respectively
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• some hair decolorization is seen in one year old males
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• hippocampal neurons from E17 mutants exposed to the toxic aldehyde 4-hydroxy-2-nonenal (HNE) exhibit shorter neurite length and increased apoptosis, indicating increased sensitivity to HNE and decreased ability to detoxify HNE
• cortical neurons from E17 mutants exposed to HNE also exhibit increased sensitivity to HNE, with neurons showing injury and detaching from the dish
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• higher accumulation of the toxic aldehyde 4-hydroxy-2-nonenal (HNE) in the brain, indicating inhibited HNE degradation and enhanced accumulation of reactive oxygen species end products
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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