Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cbfbtm2.1Ddg
Name:	core binding factor beta; targeted mutation 2.1, David D Ginty
MGI ID:	MGI:5698728
Synonyms:	Cbfbf
Gene:	Cbfb  Location: Chr8:105897306-105944621 bp, + strand  Genetic Position: Chr8, 53.04 cM
Alliance:	Cbfbtm2.1Ddg page

Germline Transmission:	Earliest citation of germline transmission: J:226826
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT-flanked neomycin cassette and loxP site were introduced 1 kb upstream of the transcription start site, and a second loxP site was place in intron 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:226826)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cbfb Mutation:	36 strains or lines available

Original:	J:226826 Huang S, et al., Extrinsic and intrinsic signals converge on the Runx1/CBFbeta transcription factor for nonpeptidergic nociceptor maturation. Elife. 2015;4:e10874
All:	4 reference(s)