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Gene Expression Data
Assay Details
Assay
Reference: J:199400 van den Heuvel DM, et al., Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain. PLoS One. 2013;8(2):e55828
Assay type: RNA in situ
MGI Accession ID: MGI:5693240
Gene symbol: Rgmb
Gene name: repulsive guidance molecule family member B
Probe: Rgmb cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: olfactory epithelium Present Regionally restricted 1B , 1B' Strongest expression was detected in the basal part of the olfactory epithelium.
TS24: main olfactory bulb mitral cell layer Present Regionally restricted 1B Expression was detected in ventrolateral mitral cells.
TS24: accessory olfactory bulb Weak 1B
TS24: main olfactory bulb prospective glomerular layer Strong 1B
TS24: main olfactory bulb prospective granule cell layer Strong 1B
Specimen 1M: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: olfactory epithelium Present 1M Expression was as observed at E16.5.
TS28: main olfactory bulb glomerular layer Strong Regionally restricted 1M , 1M' Strong expression was detected in periglomerular cells.
TS28: main olfactory bulb mitral cell layer Strong 1M , 1M'
TS28: main olfactory bulb granule cell layer Strong 1M' , 1M Expression was strongest in granule cells located adjacent to the inner plexiform layer.
Specimen Table S2 E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: olfactory epithelium Strong Regionally restricted Basal expression.
TS24: ethmoid bone cribriform plate Absent
TS24: main olfactory bulb ventricular layer Absent
TS24: accessory olfactory bulb Moderate
TS24: main olfactory bulb internal plexiform layer Very strong
TS24: main olfactory bulb mitral cell layer Very strong
TS24: main olfactory bulb prospective granule cell layer Very strong
TS24: main olfactory bulb prospective glomerular layer Strong
TS24: main olfactory bulb external plexiform layer Weak
Specimen Table S2 P5: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb glomerular layer Moderate
TS28: main olfactory bulb external plexiform layer Weak
TS28: main olfactory bulb internal plexiform layer Weak
TS28: main olfactory bulb mitral cell layer Very strong
TS28: anterior olfactory nucleus Strong
TS28: main olfactory bulb granule cell layer Strong
TS28: main olfactory bulb ventricular layer Strong
TS28: olfactory epithelium Strong Regionally restricted Basal expression.
TS28: ethmoid bone cribriform plate Absent
Specimen Table S2 Adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: anterior olfactory nucleus Strong
TS28: main olfactory bulb glomerular layer Strong
TS28: main olfactory bulb mitral cell layer Strong
TS28: main olfactory bulb external plexiform layer Weak
TS28: main olfactory bulb internal plexiform layer Weak
TS28: main olfactory bulb granule cell layer Moderate
TS28: main olfactory bulb ventricular layer Absent
Specimen 3B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex Moderate 3B , 3B'
TS24: cerebral cortex subventricular zone Present 3B' , 3B
TS24: cortical plate Present Regionally restricted 3B , 3B' Expression was in the upper part of the cortical plate.
TS24: telencephalon pia mater Strong 3B , 3B'
Specimen 4B: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: cortical layer V Present Graded 4B' , 4B Expression was in a medial high to lateral low gradient in the neurons of layer 5.
Specimen Table S3 E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex subventricular zone Strong
TS24: telencephalon pia mater Strong
TS24: cortical plate Strong Regionally restricted Strongest expression in the upper part.
TS24: cerebral cortex intermediate zone Moderate
TS24: cerebral cortex marginal layer Moderate
TS24: cortical subplate Moderate
TS24: cerebral cortex ventricular layer Absent
Specimen Table S3 P5: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: cerebral cortex ventricular zone Absent
TS28: cortical layer I Absent
TS28: cortical layer II Absent
TS28: cortical layer III Absent
TS28: cortical layer IV Absent
TS28: cortical layer VI Absent
TS28: cortical layer V Strong
Specimen Table S3 Adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cerebral cortex ventricular zone Moderate
TS28: cortical layer I Moderate
TS28: cortical layer II Moderate
TS28: cortical layer III Moderate
TS28: cortical layer IV Moderate
TS28: cortical layer VI Moderate
TS28: cortical layer V Strong
Specimen 6B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: hippocampal formation Weak Widespread 6B
TS24: telencephalon pia mater Present Regionally restricted 6B Prominent expression was detected in the pial layer lining the hippocampal fissure.
Specimen 6K: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA2 Present 6K
TS28: hippocampus CA3 Present 6K
TS28: dentate gyrus granule cell layer Weak 6K
TS28: dentate gyrus polymorphic layer Present 6K
Specimen Table S4 E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: hippocampus Moderate Regionally restricted Moderate expression was in the hippocampus. The CA region and the subventricular zone had strong signal.
TS24: dentate gyrus primordium Moderate
TS24: entorhinal cortex Strong
TS24: hippocampus ventricular layer Absent
Specimen Table S4 P5: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA1 Moderate
TS28: hippocampus CA2 Strong
TS28: hippocampus CA3 Very strong
TS28: dentate gyrus Moderate
TS28: dentate gyrus polymorphic layer Moderate
TS28: dentate gyrus granule cell layer Weak
TS28: dentate gyrus molecular layer Weak
TS28: hippocampus stratum oriens Weak
TS28: hippocampus stratum radiatum Weak
TS28: hippocampus stratum lacunosum Moderate
TS28: entorhinal cortex Strong
Specimen Table S4 Adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: hippocampus CA1 Strong
TS28: hippocampus CA2 Strong
TS28: hippocampus CA3 Very strong
TS28: dentate gyrus Strong
TS28: dentate gyrus granule cell layer Strong
TS28: dentate gyrus polymorphic layer Strong
TS28: hippocampus stratum oriens Moderate
TS28: entorhinal cortex Weak
TS28: hippocampus stratum lacunosum Weak
TS28: hippocampus molecular layer Absent
TS28: hippocampus stratum radiatum Absent
Specimen 8B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: medial habenular nucleus Strong 8B
TS24: lateral habenular nucleus Strong Regionally restricted 8B Strong expression was detected in the medial part of the lateral habenular nucleus.
Specimen 8E: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: medial habenular nucleus Strong 8E
TS24: lateral habenular nucleus Strong Regionally restricted 8E Strong expression was detected in the medial part of the lateral habenular nucleus.
Specimen 8O: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: midbrain Strong Regionally restricted 8O Strong expression was detected in the ventral tegmental area.
Specimen 9B: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: paraventricular thalamic nucleus Present 9B
TS28: lateral habenular nucleus Strong 9B
TS28: medial habenular nucleus Strong Regionally restricted 9B Expression was detected in the lateral aspect of the medial habenular nucleus.
Specimen 9H: postnatal adult (more )
Structure Level Pattern Image Note
TS28: paraventricular thalamic nucleus Present 9H
TS28: lateral habenular nucleus Strong 9H
TS28: medial habenular nucleus Strong Regionally restricted 9H Expression was detected in the lateral aspect of the medial habenular nucleus.
Specimen Table S5 E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: midbrain Present Regionally restricted Expression was moderate in the substantia nigra, and was strong in the ventral tegmental area.
TS24: telencephalon septum Moderate
TS24: corpus striatum Very strong
TS24: lateral habenular nucleus Very strong
TS24: medial habenular nucleus Very strong
TS24: interpeduncular nucleus Strong
TS24: thalamus Strong
TS24: hypothalamus Strong Regionally restricted Expression was strong in the lateral hypothalamus.
Specimen Table S5 P5: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: lateral habenular nucleus Very strong
TS28: medial habenular nucleus Very strong
TS28: hypothalamus lateral zone Moderate
TS28: interpeduncular nucleus Moderate
TS28: thalamus Moderate
TS28: corpus striatum Weak
TS28: substantia nigra Weak
TS28: telencephalon septum Weak
TS28: ventral tegmental area Weak
TS28: paraventricular thalamic nucleus Strong
Specimen Table S5 Adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: lateral habenular nucleus Very strong
TS28: interpeduncular nucleus Strong
TS28: medial habenular nucleus Strong
TS28: hypothalamus lateral zone Moderate
TS28: paraventricular thalamic nucleus Moderate
TS28: substantia nigra Moderate
TS28: telencephalon septum Moderate
TS28: thalamus Moderate
TS28: ventral tegmental area Moderate
TS28: corpus striatum Weak
Specimen 11B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebellum external granule cell layer Present Regionally restricted 11B Expression was detected in a subset of cells in the inner part of the EGL.
TS24: cerebellum Purkinje cell cluster Present 11B
TS24: deep cerebellar nucleus Present 11B
Specimen 11H: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present Regionally restricted 11H Expression was detected in the inner EGL.
TS28: cerebellum Purkinje cell layer Present 11H
TS28: cerebellum internal granule cell layer Weak 11H
Specimen 11N: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 11N
TS28: cerebellum granule cell layer Present 11N
Specimen Table S6 E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebellum external granule cell layer Moderate Regionally restricted Expression detected in the inner EGL layer.
TS24: cerebellum Purkinje cell cluster Moderate
TS24: deep cerebellar nucleus Strong
TS24: cerebellum ventricular layer Absent
Specimen Table S6 P5: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Strong Regionally restricted Expression was strong in inner EGL layers.
TS28: cerebellum Purkinje cell layer Moderate
TS28: cerebellum internal granule cell layer Moderate
Specimen Table S6 Adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong
TS28: cerebellum granule cell layer Strong
TS28: cerebellum molecular layer Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory