Ptch1 In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:70423 Eggenschwiler JT, et al., Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature. 2001 Jul 12;412(6843):194-8
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:5689842
Gene symbol:	Ptch1
Gene name:	patched 1

Reporter:	lacZ
	Direct Detection

Results

Specimen 2a WT: embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS15: neural tube	Present	Regionally restricted	2a WT	Expression is ventral.

Specimen 2a opb2: embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺, Rab23^opb2/Rab23^opb2 (more

)

Structure	Level	Pattern	Image	Note
TS15: neural tube	Present		2a opb2	Expression is expanded dorsally in this mutant.

Specimen 2a Shh: embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺, Shh^tm1Chg/Shh^tm1Chg (more

)

Structure	Level	Pattern	Image	Note
TS15: gut	Present	Regionally restricted	2a Shh
TS15: neural tube	Absent		2a Shh

Specimen 2a Shh opb2: embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺, Rab23^opb2/Rab23^opb2, Shh^tm1Chg/Shh^tm1Chg (more

)

Structure	Level	Pattern	Image	Note
TS15: neural tube	Present		2a Shh opb2	Expression is expanded dorsally in this mutant.

Specimen 2b WT: embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS15: neural tube	Present	Regionally restricted	2b WT	Expression is ventral.

Specimen 2b opb2: embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺, Rab23^opb2/Rab23^opb2 (more

)

Structure	Level	Pattern	Image	Note
TS15: neural tube	Present		2b opb2	Expression is expanded dorsally in this mutant.

Specimen 2b Shh: embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺, Shh^tm1Chg/Shh^tm1Chg (more

)

Structure	Level	Pattern	Image	Note
TS15: neural tube	Absent		2b Shh

Specimen 2b Shh opb2: embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺, Rab23^opb2/Rab23^opb2, Shh^tm1Chg/Shh^tm1Chg (more

)

Structure	Level	Pattern	Image	Note
TS15: neural tube	Present		2b Shh opb2	Expression is expanded dorsally in this mutant and is higher in ventral than in dorsal cells.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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