Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(CAG-lacZ,-FUS*R521G,-EGFP)673Gyu
Name:	transgene insertion 673, Gang Yu
MGI ID:	MGI:5662097
Synonyms:	CAG-Z-FUSR521G (673), CAG-Z-FUSR521G-IRES-EGFP founder line 673
Transgene:	Tg(CAG-lacZ,-FUS*R521G,-EGFP)673Gyu  Location: unknown
Alliance:	Tg(CAG-lacZ,-FUS*R521G,-EGFP)673Gyu page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter) Mutation:    Insertion   Tg(CAG-lacZ,-FUS*R521G,-EGFP)673Gyu expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human FUS (2521) Fus  (MGI:1353633) The human sequence is modified to result in the amino acid substitution Arg521Gly.   Mutation details: This transgene consists of the cytomegalovirus immediate early enhancer-chicken beta-actin hybrid (CAG) promoter, a floxed lacZ gene, human FUS cDNA with the R521C mutation, IRES, and EGFP coding sequences. Cre-excision of the loxP flanked lacZ DNA allows for translation of FUS and EGFP. Two lines were generated: 673, and 682. Line 682 was chosen as a representative line. (J:216672)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:216672 Sephton CF, et al., Activity-dependent FUS dysregulation disrupts synaptic homeostasis. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4769-78
All:	1 reference(s)