Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rack1tm1Sbif
Name:	receptor for activated C kinase 1; targeted mutation 1, Stefano Biffo
MGI ID:	MGI:5660834
Synonyms:	deltaF
Gene:	Rack1  Location: Chr11:48691187-48697068 bp, + strand  Genetic Position: Chr11, 28.77 cM
Alliance:	Rack1tm1Sbif page

Germline Transmission:	Earliest citation of germline transmission: J:223207
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Hypomorph) Mutations:    Insertion, Intragenic deletion   Mutation details: Aberrant integration of a targeting construct resulted in a 142 nucleotide deletion in intron 2 and insertion of a loxP-flanked Neo cassette in intron 3 of the gene. This mutation resulted in hypomorphic expression of the gene. (J:223207)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rack1 Mutation:	56 strains or lines available

Original:	J:223207 Volta V, et al., RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency. Cell Mol Life Sci. 2013 Apr;70(8):1439-50
All:	1 reference(s)