Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Mc4rtm3.1(cre)Lowl
Name:	melanocortin 4 receptor; targeted mutation 3.1, Bradford B Lowell
MGI ID:	MGI:5647881
Synonyms:	mc4r-t2a-cre
Gene:	Mc4r  Location: Chr18:66990776-66993558 bp, - strand  Genetic Position: Chr18, 39.72 cM, cytoband E1
Alliance:	Mc4rtm3.1(cre)Lowl page

Germline Transmission:	Earliest citation of germline transmission: J:222852
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Mc4rtm3.1(cre)Lowl expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Mc4r (MGI:99457)   Mutation details: A t2a cleaving peptide from Thosea asigna virus and a cre recombinase gene were inserted downstream of the stop codon. (J:222852)

Activity:	Tissue activity of this recombinase allele
Driver:	Mc4r (mouse) Summary of all recombinase alleles driven by Mc4r. Comparative matrix view of recombinase activities Alliance mouse Mc4r gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mc4r Mutation:	44 strains or lines available

Original:	J:222852 Garfield AS, et al., A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015 Jun;18(6):863-71
All:	18 reference(s)