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Gene Expression Data
Assay Details
Assay
Reference: J:79898 Kochilas L, et al., The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev Biol. 2002 Nov 1;251(1):157-66
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5645339
Gene symbol: Acta2
Gene name: actin alpha 2, smooth muscle, aorta
Results
Specimen 5F: embryonic day 10.5; Taglntm1Msp/Tagln+ (more )
Note: Double labeled: brown - actin; blue - Tagln (SM22a; assay MGI:5645349).
Structure Level Pattern Image Note
TS17: 3rd arch artery Present 5F Expression is present in smooth muscle cells.
TS17: 4th arch artery Present 5F Expression is present in smooth muscle cells.
TS17: 6th arch artery Present 5F Expression is present in smooth muscle cells.
Specimen 5G: embryonic day 10.5; Del(16Dgcr2-Hira)1Rak/+, Taglntm1Msp/Tagln+ (more )
Structure Level Pattern Image Note
TS17: 3rd arch artery Present 5G Expression is present in smooth muscle cells.
TS17: 4th arch artery Absent 5G In the mutant no smooth muscle differentiation was seen in 6 of 10 right arches and 4 of 10 left arches.
Specimen 5H: embryonic day 10.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Pax3-cre)1Joe/0 (more )
Note: Conditional mutant. Double labeled: brown - actin; blue - Cre reporter label of neural crest cells.
Structure Level Pattern Image Note
TS17: branchial arch artery Present 5H Expression is present in smooth muscle cells.
Specimen 5I: embryonic day 10.5; Del(16Dgcr2-Hira)1Rak/+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Tg(Pax3-cre)1Joe/0 (more )
Note: Conditional mutant. Double labeled: brown - actin; blue - Cre reporter label of neural crest cells.
Structure Level Pattern Image Note
TS17: branchial arch artery Trace 5I In the mutant there is a paucity of smooth muscle differentiation.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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