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Gene Expression Data
Assay Details
Assay
Reference: J:198000 Hoffmann S, et al., Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia. Basic Res Cardiol. 2013;108(2):339
Assay type: RNA in situ
MGI Accession ID: MGI:5641476
Gene symbol: Hcn4
Gene name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Probe: Hcn4 probe1
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2Aa: embryonic day 12.5 (more )
Note: Double labeled: red - Hcn4; blue - Isl1 (assay MGI:5638681).
Structure Level Pattern Image Note
TS20: sinoatrial node Present 2Aa
Specimen 2Aa': embryonic day 12.5 (more )
Note: Double labeled: red - Hcn4; blue - Isl1 (assay MGI:5638681).
Structure Level Pattern Image Note
TS20: sinoatrial node Present 2Aa'
Specimen 2Ab: embryonic day 12.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Double labeled: red - Hcn4; blue - Isl1 (assay MGI:5638681).
Structure Level Pattern Image Note
TS20: sinoatrial node Present 2Ab Expression was somewhat reduced in the mutant compared to wild type.
Specimen 2Ab': embryonic day 12.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Double labeled: red - Hcn4; blue - Isl1 (assay MGI:5638681).
Structure Level Pattern Image Note
TS20: sinoatrial node Present Regionally restricted 2Ab' Expression was somewhat reduced in the mutant compared to wild type.
Specimen 2Ac: embryonic day 13.5 (more )
Note: Double labeled: red - Hcn4; blue - Isl1 (assay MGI:5638681).
Structure Level Pattern Image Note
TS21: sinoatrial node Present 2Ac
Specimen 2Ac': embryonic day 13.5 (more )
Note: Double labeled: red - Hcn4; blue - Isl1 (assay MGI:5638681).
Structure Level Pattern Image Note
TS21: sinoatrial node Present 2Ac'
Specimen 2Ad: embryonic day 13.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Double labeled: red - Hcn4; blue - Isl1 (assay MGI:5638681).
Structure Level Pattern Image Note
TS21: sinoatrial node Present 2Ad Expression was somewhat reduced in the mutant compared to wild type.
Specimen 2Ad': embryonic day 13.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Double labeled: red - Hcn4; blue - Isl1 (assay MGI:5638681).
Structure Level Pattern Image Note
TS21: sinoatrial node Present 2Ad' Expression was somewhat reduced in the mutant compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory