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Gene Expression Data
Assay Details
Assay
Reference: J:198000 Hoffmann S, et al., Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia. Basic Res Cardiol. 2013;108(2):339
Assay type: RNA in situ
MGI Accession ID: MGI:5638681
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Probe: Isl1 cDNA9
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: sinoatrial node Present 1B Isl1

Specimen 1Ca: embryonic day 11.5 (more )
Note: Ventral view.
Structure Level Pattern Image Note
TS19: outflow tract Present 1Ca
TS19: sinoatrial node Present 1Ca

Specimen 1Cb: embryonic day 11.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Ventral view.
Structure Level Pattern Image Note
TS19: outflow tract Present 1Cb
TS19: sinoatrial node Absent 1Cb

Specimen 1Ca': embryonic day 11.5 (more )
Note: Dorsal view.
Structure Level Pattern Image Note
TS19: outflow tract Present 1Ca'
TS19: sinoatrial node Present 1Ca'

Specimen 1Cb': embryonic day 11.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Dorsal view.
Structure Level Pattern Image Note
TS19: outflow tract Present 1Cb'
TS19: sinoatrial node Absent 1Cb'

Specimen 2Aa: embryonic day 12.5 (more )
Note: Double labeled: blue - Isl1; red - Hcn4 (assay MGI:5641476).
Structure Level Pattern Image Note
TS20: sinoatrial node Present 2Aa

Specimen 2Aa': embryonic day 12.5 (more )
Note: Double labeled: blue - Isl1; red - Hcn4 (assay MGI:5641476).
Structure Level Pattern Image Note
TS20: sinoatrial node Present 2Aa'

Specimen 2Ab: embryonic day 12.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Double labeled: blue - Isl1; red - Hcn4 (assay MGI:5641476).
Structure Level Pattern Image Note
TS20: sinoatrial node Absent 2Ab

Specimen 2Ab': embryonic day 12.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Double labeled: blue - Isl1; red - Hcn4 (assay MGI:5641476).
Structure Level Pattern Image Note
TS20: sinoatrial node Absent 2Ab'

Specimen 2Ac: embryonic day 13.5 (more )
Note: Double labeled: blue - Isl1; red - Hcn4 (assay MGI:5641476).
Structure Level Pattern Image Note
TS21: sinoatrial node Present 2Ac

Specimen 2Ac': embryonic day 13.5 (more )
Note: Double labeled: blue - Isl1; red - Hcn4 (assay MGI:5641476).
Structure Level Pattern Image Note
TS21: sinoatrial node Present 2Ac'

Specimen 2Ad: embryonic day 13.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Double labeled: blue - Isl1; red - Hcn4 (assay MGI:5641476).
Structure Level Pattern Image Note
TS21: sinoatrial node Absent 2Ad

Specimen 2Ad': embryonic day 13.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Double labeled: blue - Isl1; red - Hcn4 (assay MGI:5641476).
Structure Level Pattern Image Note
TS21: sinoatrial node Absent 2Ad'

Specimen S1Aa: embryonic day 12.5 (more )
Note: Ventral view.
Structure Level Pattern Image Note
TS20: outflow tract Present S1Aa

Specimen S1Ab: embryonic day 12.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Ventral view.
Structure Level Pattern Image Note
TS20: outflow tract Present S1Ab

Specimen S1Aa': embryonic day 12.5 (more )
Note: Dorsal view.
Structure Level Pattern Image Note
TS20: sinoatrial node Present S1Aa'

Specimen S1Ab': embryonic day 12.5; Shox2tm1Acgg/Shox2tm1Acgg (more )
Note: Dorsal view.
Structure Level Pattern Image Note
TS20: sinoatrial node Absent S1Ab'


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory