Tg(Prnp-FUS)17Ljh
Transgene Detail
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| Symbol: |
Tg(Prnp-FUS)17Ljh |
| Name: |
transgene insertion 17, Lawrence Hayward |
| MGI ID: |
MGI:5621048 |
| Synonyms: |
FUSWT, line PWT17 |
| Transgene: |
Tg(Prnp-FUS)17Ljh Location: unknown
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| Alliance: |
Tg(Prnp-FUS)17Ljh page
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| Strain of Origin: |
(C57BL/6 x SJL)F2
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Prnp-FUS)17Ljh expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
FUS (2521) |
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Mutation details: The transgenic construct contains a cDNA sequence encoding the wild-type human fused in sarcoma protein (FUS). The cDNA sequence is inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene. Line PWT17 is identified with ~2 copies of the transgene and results in a 2-fold FUS overexpression.
(J:218094)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:218094 Tibshirani M, et al., Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1. Hum Mol Genet. 2015 Feb 1;24(3):773-86 |
| All: |
1 reference(s) |
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Analysis Tools
