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Gene Expression Data
Assay Details
Assay
Reference: J:218012 Rutlin M, et al., The cellular and molecular basis of direction selectivity of Adelta-LTMRs. Cell. 2014 Dec 18;159(7):1640-51
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5617192
Gene symbol: Ntrk2
Gene name: neurotrophic tyrosine kinase, receptor, type 2
Reporter: GFP
Antibody: anti-GFP (Aves)
Detection system: Secondary antibody coupled to Alexa Fluor
Assay notes: The authors described two anti-GFP antibodies but did not detail which was used to obtain these data; it is possible MGI:4354373 was used instead.
Results
Specimen 5A: postnatal adult; Bdnftm1Krj/Bdnf+, Ntrk2tm2.1Ddg/Ntrk2+, Tg(KRT5-cre)5132Jlj/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: spinal nerve Present 5A Expression is present in alpha-delta low-threshold mechanoreceptor lanceolate endings associated with hair follicles.
Specimen 5B: postnatal adult; Bdnftm1Krj/Bdnftm1Krj, Ntrk2tm2.1Ddg/Ntrk2+, Tg(KRT5-cre)5132Jlj/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: spinal nerve Present 5B Expression is present in alpha-delta low-threshold mechanoreceptor lanceolate endings associated with hair follicles. These endings lack polarization in the mutant.
Specimen S5A: postnatal day 0; Ntrk2tm2.1Ddg/Ntrk2+ (more )
Structure Level Pattern Image Note
TS27: dorsal root ganglion Present S5A Expression is present in alpha-delta low-threshold mechanoreceptors.
Specimen S5B: postnatal day 0; Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg (more )
Structure Level Pattern Image Note
TS27: dorsal root ganglion Trace S5B Expression is present in alpha-delta low-threshold mechanoreceptors. These neurons are nearly completely lost in the mutant.
Specimen S5C: postnatal day 0; Bdnftm1Krj/Bdnftm1Krj, Ntrk2tm2.1Ddg/Ntrk2+ (more )
Structure Level Pattern Image Note
TS27: dorsal root ganglion Present S5C Expression is present in alpha-delta low-threshold mechanoreceptors. There is a 66 percent reduction in the number of these neurons in the mutant compared to littermate controls.
Specimen S5E: postnatal day 0; Bdnftm1Krj/Bdnftm1Krj, Ntrk2tm2.1Ddg/Ntrk2+ (more )
Structure Level Pattern Image Note
TS27: dorsal root ganglion Present S5E Expression is present in thoracic-level neurons.
Specimen S5F: postnatal day 0; Bdnftm1Krj/Bdnftm1Krj, Ntrk2tm2.1Ddg/Ntrk2+, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: dorsal root ganglion Present S5F Expression is present in thoracic-level neurons. There is a 50 percent reduction in the number of these neurons in the mutant compared to littermate controls.
Specimen S5G: postnatal day 0; Bdnftm1Krj/Bdnftm1Krj, Ntrk2tm2.1Ddg/Ntrk2+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: dorsal root ganglion Present S5G Expression is present in thoracic-level neurons. The numbers of these neurons are comparable in the mutant and littermate controls.
Specimen S5H: postnatal adult; Bdnftm1Krj/Bdnftm1Krj, Ntrk2tm2.1Ddg/Ntrk2+, Tg(KRT5-cre)5132Jlj/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present S5H Expression is present in thoracic-level neurons. The numbers of these neurons are comparable in the mutant and littermate controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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