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Gene Expression Data
Assay Details
Assay
Reference: J:212073 Camarena V, et al., Disruption of Mbd5 in mice causes neuronal functional deficits and neurobehavioral abnormalities consistent with 2q23.1 microdeletion syndrome. EMBO Mol Med. 2014;6(8):1003-15
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5615205
Gene symbol: Mbd5
Gene name: methyl-CpG binding domain protein 5
Reporter: lacZ
Direct Detection
Results
Specimen 3A: postnatal month 1; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS28: cerebellum granule cell layer Strong 3A
TS28: hypothalamus Strong 3A
TS28: main olfactory bulb granule cell layer Strong 3A
TS28: main olfactory bulb mitral cell layer Strong 3A
TS28: thalamus Strong 3A
TS28: main olfactory bulb Present 3A Expression was stronger in the anterior olfactory nuclei.
TS28: cerebellum Present 3A
TS28: cerebral cortex Present 3A
TS28: corpus striatum Present 3A
TS28: dentate gyrus Present 3A
TS28: hippocampus CA1 Present 3A
TS28: hippocampus CA2 Present 3A
TS28: hippocampus CA3 Present 3A

Specimen 3B: postnatal month 1; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Note: Triple labeled: black - Mbd5 reporter; red - Rbfox3 (assay MGI:5615210); green - Gfap (assay MGI:5615211).
Structure Level Pattern Image Note
TS28: brain Present 3B X-gal , 3B merged Expression is in neurons, not astrocytes.

Specimen 3C top: postnatal month 1; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS28: adenohypophysis Present 3C top
TS28: adenohypophysis pars intermedia Present 3C top

Specimen 3C bottom: postnatal month 1; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS28: adenohypophysis Present 3C bottom
TS28: adenohypophysis pars intermedia Present 3C bottom

Specimen S2A Kidney: postnatal; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS28: metanephros Present S2A Kidney

Specimen S2A Liver: postnatal; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS28: liver Weak S2A Liver

Specimen S2A Lung: postnatal; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS28: lung Weak S2A Lung

Specimen S2A Spleen: postnatal; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS28: spleen Weak S2A Spleen

Specimen S2A Heart: postnatal; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS28: heart Present S2A Heart

Specimen S2A S. Intestine: postnatal; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS28: small intestine Weak S2A S. Intestine

Specimen S2B E5.5: embryonic day 5.5; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS8: embryo Present S2B E5.5

Specimen S2B E15: embryonic day 15.0; Mbd5Gt(Ayu21-B205)Imeg/Mbd5+ (more )
Structure Level Pattern Image Note
TS23: forebrain Strong S2B E15
TS23: heart Strong S2B E15
TS23: hindbrain Strong S2B E15
TS23: midbrain Strong S2B E15
TS23: spinal cord Strong S2B E15


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory