Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rspo3tm1.1Arte
Name:	R-spondin 3; targeted mutation 1.1, TaconicArtemis
MGI ID:	MGI:5609537
Gene:	Rspo3  Location: Chr10:29329102-29411863 bp, - strand  Genetic Position: Chr10, 16.64 cM, cytoband A4
Alliance:	Rspo3tm1.1Arte page

Germline Transmission:	Earliest citation of germline transmission: J:215739
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the selection cassette. RT-PCR confirmed the absence of transcript expression. (J:215739)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rspo3 Mutation:	14 strains or lines available

Original:	J:215739 Kazanskaya O, et al., The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development. 2008 Nov;135(22):3655-64
All:	4 reference(s)