Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dseltm1Mmac
Name:	dermatan sulfate epimerase-like; targeted mutation 1, Marco Maccarana
MGI ID:	MGI:5583872
Gene:	Dsel  Location: Chr1:111786432-111792648 bp, - strand  Genetic Position: Chr1, 50.84 cM
Alliance:	Dseltm1Mmac page

Germline Transmission:	Earliest citation of germline transmission: J:213195
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced the coding exon containing the translation initation site. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts and skin. (J:213195)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

16 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dsel Mutation:	50 strains or lines available

Original:	J:213195 Bartolini B, et al., Mouse development is not obviously affected by the absence of dermatan sulfate epimerase 2 in spite of a modified brain dermatan sulfate composition. Glycobiology. 2012 Jul;22(7):1007-16
All:	3 reference(s)