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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dseltm1Mmac
targeted mutation 1, Marco Maccarana
MGI:5583872
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dseltm1Mmac/Dseltm1Mmac involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5583880


Genotype
MGI:5583880
hm1
Allelic
Composition		 Dseltm1Mmac/Dseltm1Mmac
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dseltm1Mmac mutation (1 available); any Dsel mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal mineral level ( J:213195 )
• reduced iduronic acid content in the brain and kidney chondroitin sulfate/dermatan sulfate (CS/DS)
abnormal enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity in the skin, lung, liver, spleen, kidney and brain
decreased spleen enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity
decreased brain enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity
decreased kidney enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity
decreased liver enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity
decreased lung enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity

hematopoietic system
decreased spleen enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity

nervous system
nervous system phenotype ( J:213195 )
N
• brains exhibit normal extracellular matrix
decreased brain enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity

liver/biliary system
decreased liver enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity

renal/urinary system
decreased kidney enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity

respiratory system
decreased lung enzyme/coenzyme activity ( J:213195 )
• reduced epimerase activity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/07/2026
MGI 6.24 		The Jackson Laboratory