Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tyrem2Utr
Name:	tyrosinase; endonuclease-mediated mutation 2, Ken-ichi Yagami
MGI ID:	MGI:5582798
Synonyms:	TyrG291T
Gene:	Tyr  Location: Chr7:87073979-87142637 bp, - strand  Genetic Position: Chr7, 49.01 cM
Alliance:	Tyrem2Utr page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Not Specified) Mutation:    Single point mutation   Mutation details: CRISPR/Cas9 endonuclease-mediated the nucleotide substitution G to T at position 291. This allele was derived from mouse founder line #1 which also carried the 5 nucleotide deletion allele Tyrem1Utr in trans. (J:213052)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:	375 strains or lines available

Original:	J:213052 Mizuno S, et al., Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system. Mamm Genome. 2014 Aug;25(7-8):327-34
All:	2 reference(s)