Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tardbpm1H
Name:	TAR DNA binding protein; mutation 1, Harwell
MGI ID:	MGI:5575763
Synonyms:	TardbpQ101X
Gene:	Tardbp  Location: Chr4:148696839-148711476 bp, - strand  Genetic Position: Chr4, 78.77 cM
Alliance:	Tardbpm1H page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) (Hypomorph) Mutation:    Single point mutation   Mutation details: ENU mutagenesis induced a C to T transition in exon 3 that results in the amino acid substitution of a glutamine to Stop codon nonsense mutation (Q101X). (J:211620)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tardbp Mutation:	60 strains or lines available

Original:	J:211620 Ricketts T, et al., A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects. PLoS One. 2014;9(1):e85962
All:	1 reference(s)