Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aspmtm1.2Kxi
Name:	abnormal spindle microtubule assembly; targeted mutation 1.2, Kyoko Itoh
MGI ID:	MGI:5573152
Gene:	Aspm  Location: Chr1:139382510-139421829 bp, + strand  Genetic Position: Chr1, 61.45 cM, cytoband F
Alliance:	Aspmtm1.2Kxi page

Germline Transmission:	Earliest citation of germline transmission: J:205524
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. Cre-mediated recombination removed exons 2 and 3. This deletion introduces a frameshift and premature stop codon at position 95. (J:205524)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aspm Mutation:	138 strains or lines available

Original:	J:205524 Fujimori A, et al., Disruption of Aspm causes microcephaly with abnormal neuronal differentiation. Brain Dev. 2014 Sep;36(8):661-9
All:	2 reference(s)