Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sirt3tm1.1Auw
Name:	sirtuin 3; targeted mutation 1.1, Johan Auwerx
MGI ID:	MGI:5556075
Synonyms:	Sirt3L2
Gene:	Sirt3  Location: Chr7:140443579-140462222 bp, - strand  Genetic Position: Chr7, 86.07 cM, cytoband F4
Alliance:	Sirt3tm1.1Auw page

Germline Transmission:	Earliest citation of germline transmission: J:207274
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting vector is designed to insert loxP sites flanking exons 2-3 of the gene, and a FRT-flanked neomycin selection cassette was inserted upstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:207274)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sirt3 Mutation:	30 strains or lines available

Original:	J:207274 Fernandez-Marcos PJ, et al., Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep. 2012;2:425
All:	12 reference(s)