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Becn2tm1.1Blev
Targeted Allele Detail
Summary
Symbol: Becn2tm1.1Blev
Name: beclin 2; targeted mutation 1.1, Beth Levine
MGI ID: MGI:5550535
Gene: Becn2  Location: Chr1:175747895-175749791 bp, + strand  Genetic Position: Chr1, Syntenic
Alliance: Becn2tm1.1Blev page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203842
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129 x C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced exons 1 and 2. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:203842)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 25 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Becn2 Mutation:  0 strains or lines available
References
Original:  J:203842 He C, et al., Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 2013 Aug 29;154(5):1085-99
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory