Phenotypes associated with this allele

• Allele Symbol: Becn2^tm1.1Blev
• Allele Name: targeted mutation 1.1, Beth Levine
• Allele ID: MGI:5550535
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Becn2^tm1.1Blev/Becn2^tm1.1Blev	B6.Cg-Becn2^tm1.1Blev	MGI:5550538
ht2	Becn2^tm1.1Blev/Becn2^+	B6.Cg-Becn2^tm1.1Blev	MGI:5550539

Genotype
MGI:5550538

hm1

• Allelic Composition: Becn2^tm1.1Blev/Becn2^tm1.1Blev
• Genetic Background: B6.Cg-Becn2^tm1.1Blev

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts

mortality/aging

embryonic lethality, incomplete penetrance ( J:203842 )

• fewer than expected mice are present at E8.5

• fewer than expected mice are present between E13.5 and E14

preweaning lethality, incomplete penetrance ( J:203842 )

• fewer than expected mice are present at E8.5

• fewer than expected mice are present between E13.5 and E14

• fewer than expected mice are present between E16.5 and E18

• fewer than expected mice are present at weaning

cellular

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts

Genotype
MGI:5550539

ht2

• Allelic Composition: Becn2^tm1.1Blev/Becn2⁺
• Genetic Background: B6.Cg-Becn2^tm1.1Blev

homeostasis/metabolism

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts

increased susceptibility to diet-induced obesity ( J:203842 )

• when fed a high fat diet

increased circulating glucose level ( J:203842 )

• in a glucose or insulin tolerance test whether fed a regular or high fat diet

impaired glucose tolerance ( J:203842 )

• when fed a regular or high fat diet

• however, rimonabant treatment decreases glucose intolerance

insulin resistance ( J:203842 )

• when fed a regular or high fat diet

growth/size/body

increased body weight ( J:203842 )

• when fed a regular or high fat diet

increased susceptibility to diet-induced obesity ( J:203842 )

• when fed a high fat diet

behavior/neurological

increased food intake ( J:203842 )

• when fed a regular or high fat diet

cellular

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts