All Phenotypes Becn2<tm1.1Blev> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Becn2^tm1.1Blev
targeted mutation 1.1, Beth Levine
MGI:5550535

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Becn2^tm1.1Blev/Becn2^tm1.1Blev	B6.Cg-Becn2^tm1.1Blev	MGI:5550538
ht2	Becn2^tm1.1Blev/Becn2⁺	B6.Cg-Becn2^tm1.1Blev	MGI:5550539

Allelic Composition	Becn2^tm1.1Blev/Becn2^tm1.1Blev
Genetic Background	B6.Cg-Becn2^tm1.1Blev

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn2^tm1.1Blev mutation (0 available); any Becn2 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts

mortality/aging

preweaning lethality, incomplete penetrance ( J:203842 )

• fewer than expected mice are present at E8.5

• fewer than expected mice are present between E13.5 and E14

• fewer than expected mice are present between E16.5 and E18

• fewer than expected mice are present at weaning

embryonic lethality, incomplete penetrance ( J:203842 )

• fewer than expected mice are present at E8.5

• fewer than expected mice are present between E13.5 and E14

cellular

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts

Allelic Composition	Becn2^tm1.1Blev/Becn2⁺
Genetic Background	B6.Cg-Becn2^tm1.1Blev

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn2^tm1.1Blev mutation (0 available); any Becn2 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts

increased susceptibility to diet-induced obesity ( J:203842 )

• when fed a high fat diet

increased circulating glucose level ( J:203842 )

• in a glucose or insulin tolerance test whether fed a regular or high fat diet

impaired glucose tolerance ( J:203842 )

• when fed a regular or high fat diet

• however, rimonabant treatment decreases glucose intolerance

insulin resistance ( J:203842 )

• when fed a regular or high fat diet

growth/size/body

increased body weight ( J:203842 )

• when fed a regular or high fat diet

increased susceptibility to diet-induced obesity ( J:203842 )

• when fed a high fat diet

behavior/neurological

increased food intake ( J:203842 )

• when fed a regular or high fat diet

cellular

impaired autophagy ( J:203842 )

• impaired basal and starvation-induced autophagy in mouse embryonic fibroblasts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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