Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdgfatm2Cbet
Name:	platelet derived growth factor, alpha; targeted mutation 2, Christer Betsholtz
MGI ID:	MGI:5548172
Synonyms:	Pdgfadeltaex6
Gene:	Pdgfa  Location: Chr5:138961769-138983125 bp, - strand  Genetic Position: Chr5, 77.65 cM
Alliance:	Pdgfatm2Cbet page

Germline Transmission:	Earliest citation of germline transmission: J:205009
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Hypomorph, Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette inserted into intron 5, deleting the 5' splice site upstream of exon 6. This allele is predicted to produce only the short form transcript but not express the long form. Q-PCR confirmed reduced total transcript expression in the lung and skin, but not other tissues. Authors state that this allele might be hypomorphic in the lungs but not other tissues. (J:205009)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdgfa Mutation:	19 strains or lines available

Original:	J:205009 Andrae J, et al., Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A. Mol Cell Biol. 2013 Oct;33(20):4030-40
All:	1 reference(s)