Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Car7tm1.1Kkai
Name:	carbonic anhydrase 7; targeted mutation 1.1, Kai Kaila
MGI ID:	MGI:5543604
Gene:	Car7  Location: Chr8:105261326-105276979 bp, + strand  Genetic Position: Chr8, 53.04 cM, cytoband D1
Alliance:	Car7tm1.1Kkai page

Germline Transmission:	Earliest citation of germline transmission: J:200079
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neomycin resistance cassette inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 7. Cre-mediated recombination removed the neomycin resistance cassette and exons 5 through 7. Western blot analysis confirmed the absence of protein expression in the hippocampus. (J:200079)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Car7 Mutation:	17 strains or lines available

Original:	J:200079 Ruusuvuori E, et al., Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J. 2013 Aug 14;32(16):2275-86
All:	2 reference(s)