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Gene Expression Data
Assay Details
Assay
Reference: J:119933 Lewis SL, et al., Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse. Mech Dev. 2007 Feb;124(2):157-165
Assay type: RNA in situ
MGI Accession ID: MGI:5532291
Gene symbol: Dkk1
Gene name: dickkopf WNT signaling pathway inhibitor 1
Probe: Dkk1 probe4
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 6.0 (more )
Note: Pre-streak embryo.
Structure Level Pattern Image Note
TS8: anterior visceral endoderm Present Regionally restricted 1A Expression was detected in a population of cells in the proximal-most region of the anterior visceral endoderm.
Specimen 1B: embryonic day 7.0 (more )
Note: Mid-streak embryo.
Structure Level Pattern Image Note
TS10: embryo endoderm Present Regionally restricted 1B Expression was detected in proximal part of the anterior endoderm.
Specimen 1C: embryonic day 7.5 (more )
Note: Late-streak embryo.
Structure Level Pattern Image Note
TS11: definitive endoderm Present 1C
TS11: mesendoderm Present Regionally restricted 1C Expression was detected in the anterior-most region of the axial mesendoderm.
Specimen 1D: embryonic day 7.75 (more )
Note: Early head-fold embryo.
Structure Level Pattern Image Note
TS12: embryo endoderm Present Regionally restricted 1D Expression was detected in anterior definitive endoderm.
TS12: mesenchyme derived from head mesoderm Present Regionally restricted 1D Expression was detected in the prechordal plate.
TS12: foregut diverticulum endoderm Present 1D
Specimen 1E: embryonic day 7.75 (more )
Note: Early head-fold embryo.
Structure Level Pattern Image Note
TS12: embryo endoderm Present Regionally restricted 1E Expression was detected in anterior definitive endoderm.
TS12: mesenchyme derived from head mesoderm Present Regionally restricted 1E Expression was detected in the prechordal plate.
Specimen 1F: embryonic day 7.75 (more )
Note: Early head-fold embryo.
Structure Level Pattern Image Note
TS12: embryo endoderm Present Regionally restricted 1F Expression was detected in anterior definitive endoderm.
TS12: foregut diverticulum endoderm Present Regionally restricted 1F Expression was detected in prospective foregut endoderm underneath the lateral margin of the neural plate.
Specimen 1G: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: future prosencephalon Present Regionally restricted 1G Expression was detected in the cephalic neural plate.
Specimen 1H: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: future prosencephalon Present Regionally restricted 1H Expression was detected in prospective forebrain neural plate.
TS13: embryo Present Regionally restricted 1H Expression was detected in midline prechordal tissue.
TS13: foregut diverticulum endoderm Present 1H
Specimen 1I: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: future hindbrain Present Regionally restricted 1I Expression was detected in prospective hindbrain neural plate.
Specimen 1J: embryonic day 8.5-8.75 (more )
Structure Level Pattern Image Note
TS13: head Present Regionally restricted 1J Expression was detected in the head folds.
TS13: foregut diverticulum endoderm Present 1J
TS13: trunk unsegmented mesenchyme Present 1J
Specimen 1K: embryonic day 8.5-8.75 (more )
Structure Level Pattern Image Note
TS13: foregut diverticulum endoderm Present Regionally restricted 1K Expression was detected in the endoderm of the ventral wall of the foregut.
Specimen 1L: embryonic day 7.0 (more )
Note: Mid-streak embryo.
Structure Level Pattern Image Note
TS10: embryo endoderm Present Regionally restricted 1L Expression was detected in the paraxial region of the anterior endoderm.
TS10: embryo Present Regionally restricted 1L Expression was distributed across the midline in the anterior-most part of the embryo.
Specimen 1M: embryonic day 7.0 (more )
Note: Mid-streak embryo.
Structure Level Pattern Image Note
TS10: embryo endoderm Present Regionally restricted 1M Expression was detected in the paraxial region of the anterior endoderm.
TS10: embryo Present Regionally restricted 1M Expression was distributed across the midline in the anterior-most part of the embryo.
Specimen 1P: embryonic day 7.0 (more )
Note: Double labeled: purple - Dkk1; orange/brown - Gsc (assay MGI:5532299).
Structure Level Pattern Image Note
TS10: embryo endoderm Present Regionally restricted 1P Expression was detected in the anterior endoderm. There was overlap with Gsc expression in the prechordal region.
Specimen 1R: embryonic day 8.0 (more )
Structure Level Pattern Image Note
TS12: embryo Present Regionally restricted 1R Expression was detected in the prechordal tissue.
Specimen 2B: embryonic day 7.0; Gsctm2Bhr/Gsctm2Bhr (more )
Structure Level Pattern Image Note
TS10: embryo endoderm Present Regionally restricted 2B Expression was detected in the anterior endoderm, as in wild type.
Specimen 2E: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: embryo Present 2E
Specimen 2F: embryonic day 8.5; Gsctm2Bhr/Gsctm2Bhr (more )
Note: Double labeled: purple - Dkk1; blue - Gsc (assay MGI:5532320).
Structure Level Pattern Image Note
TS13: embryo Present 2F Expression was reduced in the mutant compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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