Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pde8btm1Dgen
Name:	phosphodiesterase 8B; targeted mutation 1, Deltagen
MGI ID:	MGI:5526098
Gene:	Pde8b  Location: Chr13:95160962-95386844 bp, - strand  Genetic Position: Chr13, 49.22 cM
Alliance:	Pde8btm1Dgen page

Germline Transmission:	Earliest citation of germline transmission: J:203335
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 14 and 15, encoding the catalytic domain, were replaced with a lacZ gene with a nuclear localization sequence, a neomycin resistance gene and stop codons. Western blot analysis confirmed the absence of protein expression in the adrenal glands. (J:203335)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde8b Mutation:	57 strains or lines available

Original:	J:203335 Tsai LC, et al., The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Mol Pharmacol. 2011 Apr;79(4):639-48
All:	2 reference(s)