Prnp Immunohistochemistry Gene Expression Assay - GXD

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Gene Expression Data
Assay Details

Assay

Reference:	J:159669 Hajj GN, et al., Developmental expression of prion protein and its ligands stress-inducible protein 1 and vitronectin. J Comp Neurol. 2009 Nov 20;517(3):371-84
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:5514418
Gene symbol:	Prnp
Gene name:	prion protein

Antibody:	anti-PrPc
Detection system:	Secondary antibody coupled to horseradish peroxidase

Results

1A ©

Specimen 1A: embryonic day 8.0 (more

)

Structure	Level	Pattern	Image	Note
TS12: embryo	Absent		1A

1D ©

Specimen 1D: embryonic day 8.0 (more

)

Structure	Level	Pattern	Image	Note
TS12: neural tube	Absent		1D

1G ©

Specimen 1G: embryonic day 10.0 (more

)

Structure	Level	Pattern	Image	Note
TS16: dorsal root ganglion	Present		1G
TS16: future brain	Present		1G
TS16: future spinal cord	Present		1G

1J ©

Specimen 1J: embryonic day 12.0; Prnp^tm1Cwe/Prnp^tm1Cwe (more

)

Structure	Level	Pattern	Image	Note
TS20: embryo	Absent		1J

2L ©

S2L ©

Specimen 2L/S2L: embryonic day 10.0 (more

)

Structure	Level	Pattern	Image	Note
TS16: future spinal cord	Present	Graded	2L , S2L	Expressed in a gradient, with the highest levels in the ventral portion.

2T ©

S2T ©

Specimen 2T/S2T: embryonic day 14.0 (more

)

Structure	Level	Pattern	Image	Note
TS22: spinal cord	Strong		S2T , 2T	Not in a gradient.

3D ©

S3D ©

Specimen 3D/S3D: embryonic day 10.0 (more

)

Structure	Level	Pattern	Image	Note
TS16: dorsal root ganglion	Present	Graded	3D , S3D	Expression are more abundant in the axons and neurites than in the cell bodies.

3Q ©

S3Q ©

Specimen 3Q/S3Q: embryonic day 14.0 (more

)

Structure	Level	Pattern	Image	Note
TS22: dorsal root ganglion	Present	Widespread	S3Q , 3Q	Expressed in the axons, neurites and cell bodies.

4A ©

S4A ©

Specimen 4A/S4A: embryonic day 10.0 (more

)

Structure	Level	Pattern	Image	Note
TS16: heart	Strong		S4A , 4A

4B ©

S4B ©

Specimen 4B/S4B: embryonic day 14.0 (more

)

Structure	Level	Pattern	Image	Note
TS22: heart	Strong		S4B , 4B

4C ©

S4C ©

Specimen 4C/S4C: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: heart	Strong		S4C , 4C

5A ©

Specimen 5A: embryonic day 14.0 (more

)

Structure	Level	Pattern	Image	Note
TS22: metanephros	Weak		5A

5D ©

Specimen 5D: embryonic day 14.0 (more

)

Structure	Level	Pattern	Image	Note
TS22: lung	Weak		5D

5G ©

Specimen 5G: embryonic day 14.0 (more

)

Structure	Level	Pattern	Image	Note
TS22: liver	Ambiguous		5G	Low amounts. Almost undetectable.

7A ©

Specimen 7A: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: lung	Strong		7A	Expressed in cell membrane.

7D ©

Specimen 7D: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: intestine	Weak		7D

7G ©

Specimen 7G: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: skeletal muscle	Present	Diffuse	7G

7J ©

Specimen 7J: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: spinal cord	Present	Diffuse	7J

7M ©

Specimen 7M: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: liver	Strong		7M	Expressed in cell membrane.

7P ©

Specimen 7P: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: heart	Present	Diffuse	7P

7S ©

Specimen 7S: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: dorsal root ganglion	Present		7S	Nuclear localization was seen only in large neurons, whereas nuclei of accompanying satellite cells were negative.

Specimen not shown: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: renal tubule	Present
TS26: glomerular tuft	Absent

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