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Gene Expression Data
Assay Details
Assay
Reference: J:48079 Kume T, et al., The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell. 1998 Jun 12;93(6):985-96
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5510804
Gene symbol: Foxc1
Gene name: forkhead box C1
Reporter: lacZ
Direct Detection
Results
Specimen 2A: embryonic day 9.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch Present 2A
TS15: 2nd branchial arch Present 2A
TS15: head mesenchyme Present 2A
TS15: tail unsegmented mesenchyme Present 2A
TS15: sclerotome Present Regionally restricted 2A As somites differentiate the expression decreases and becomes restricted to the sclerotome.
TS15: somite Present Regionally restricted 2A As somites differentiate the expression decreases and becomes restricted to the sclerotome.

Specimen 2B: embryonic day 9.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS15: tail unsegmented mesenchyme Strong 2B Expression is strongest in somitomere 2.
TS15: sclerotome Present Regionally restricted 2B As somites differentiate the expression decreases and becomes restricted to the sclerotome.
TS15: somite Present Regionally restricted 2B As somites differentiate the expression decreases and becomes restricted to the sclerotome.

Specimen 2C: embryonic day 10.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS17: head mesenchyme Present 2C Expression includes the mesenchyme around the nasal epithelium and eye.
TS17: branchial arch Present 2C
TS17: forelimb bud mesenchyme Present 2C
TS17: heart Present 2C
TS17: axial skeleton Present 2C Expression is in the condensing prechondrogenic mesenchyme of the future axial and appendicular skeleton, including the vertebrae, limbs, ribs, and sternum.
TS17: skeleton Present 2C Expression is in the condensing prechondrogenic mesenchyme of the future axial and appendicular skeleton, including the vertebrae, limbs, ribs, and sternum.
TS17: vertebral cartilage condensation Present 2C Expression is in the condensing prechondrogenic mesenchyme of the future axial and appendicular skeleton, including the vertebrae, limbs, ribs, and sternum.

Specimen 2D: embryonic day 12.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS20: axial skeleton Present 2D Expression is in the condensing prechondrogenic mesenchyme of the future axial and appendicular skeleton, including the vertebrae, limbs, ribs, and sternum.
TS20: forelimb mesenchyme Present 2D Expression is in the condensing prechondrogenic mesenchyme of the future axial and appendicular skeleton, including the vertebrae, limbs, ribs, and sternum.
TS20: hindlimb mesenchyme Present 2D Expression is in the condensing prechondrogenic mesenchyme of the future axial and appendicular skeleton, including the vertebrae, limbs, ribs, and sternum.
TS20: rib pre-cartilage condensation Present 2D Expression is in the condensing prechondrogenic mesenchyme of the future axial and appendicular skeleton, including the vertebrae, limbs, ribs, and sternum.
TS20: skeleton Present 2D Expression is in the condensing prechondrogenic mesenchyme of the future axial and appendicular skeleton, including the vertebrae, limbs, ribs, and sternum.
TS20: vertebral cartilage condensation Present 2D Expression is in the condensing prechondrogenic mesenchyme of the future axial and appendicular skeleton, including the vertebrae, limbs, ribs, and sternum.
TS20: head mesenchyme Strong Regionally restricted 2D Expression is in the mesenchyme of the branchial arches, around the nasal epithelium and eye.

Specimen 2E,F,G,H,I: embryonic day 11.5; Foxc1tm1Blh/Foxc1+ (more )
Note: (F-I) Higher magnification of the regions indicated in (E).
Structure Level Pattern Image Note
TS19: blood vessel Present 2E , 2F Expression is in the head mesenchyme, including the developing meninges and blood vessels, and blood vessels in the neuroepithelium.
TS19: head mesenchyme Present 2E , 2F Expression is in the head mesenchyme, including the developing meninges and blood vessels, and blood vessels in the neuroepithelium.
TS19: endocardial lining Present 2E , 2G
TS19: mesonephric tubule Strong 2H , 2E
TS19: mesonephros mesenchyme Strong 2H , 2E
TS19: somite Present Regionally restricted 2I , 2E Expression is in early epithelial somites.
TS19: sclerotome Present 2E , 2I
TS19: tail unsegmented mesenchyme Present 2E , 2I

Specimen 2J: embryonic day 12.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS20: hindlimb mesenchyme Very strong 2J

Specimen 2K: embryonic day 12.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS20: skeleton Present Regionally restricted 2K Expression is in the condensing mesenchyme of the sternum primordium.
TS20: rib pre-cartilage condensation Present Regionally restricted 2K Expression is in the perichondrium of the ribs and is down-regulated in the undifferentiated chondrocytes.

Specimen 4A: embryonic day 12.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS20: eye Present Regionally restricted 4A Expression is in periocular mesenchyme and in the ectoderm of the future inner eyelids.
TS20: cornea Present Single cells 4A
TS20: hyaloid vascular plexus Present Regionally restricted 4A Expression is in endothelial cells.

Specimen 7A: embryonic day 13.5; Foxc1tm1Blh/Foxc1+ (more )
Structure Level Pattern Image Note
TS21: hindbrain meninges Present Regionally restricted 7A Expression is in arachnoid cells.
TS21: head mesenchyme Present Regionally restricted 7A Expression is in mesenchyme overlying the meninges' arachnoid cells.

Specimen 7B: embryonic day 13.5; Foxc1tm1Blh/Foxc1tm1Blh (more )
Structure Level Pattern Image Note
TS21: hindbrain meninges Present Regionally restricted 7B There are fewer expressing cells in this mutant.
TS21: skin Absent 7B


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory