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Gene Expression Data
Assay Details
Assay
Reference: J:182715 Monahan P, et al., p21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis. Mech Dev. 2012 Jan-Feb;128(11-12):640-52
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5507700
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Antibody: anti-Ki67 (TEC-3; M7249)
Detection system: Secondary antibody coupled to Cy3
Assay notes: Fixative was 3.8% formaldehyde.
Results
Specimen 3A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: Rathke's pouch Present 3A
Specimen 3B: embryonic day 10.5; Cdkn1atm1Led/Cdkn1atm1Led (more )
Structure Level Pattern Image Note
TS17: Rathke's pouch Present 3B Expression in this mutant is the same as in wild-type.
Specimen 3E: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: Rathke's pouch Present 3E
Specimen 3F: embryonic day 11.5; Cdkn1atm1Led/Cdkn1atm1Led (more )
Structure Level Pattern Image Note
TS19: Rathke's pouch Present 3F Expression in this mutant is the same as in wild-type.
Specimen 3I: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: remnant of Rathke's pouch Present 3I
Specimen 3J: embryonic day 12.5; Cdkn1atm1Led/Cdkn1atm1Led (more )
Structure Level Pattern Image Note
TS20: remnant of Rathke's pouch Present 3J Expression in this mutant is the same as in wild-type.
Specimen 4E: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: adenohypophysis Present Scattered 4E
TS24: adenohypophysis pars intermedia Present Scattered 4E
Specimen 4F: embryonic day 16.5; Cdkn1atm1Led/Cdkn1atm1Led (more )
Structure Level Pattern Image Note
TS24: adenohypophysis Present Scattered 4F The authors state that there appears to be an increase in positive cells in this mutant.
TS24: adenohypophysis pars intermedia Present Scattered 4F The authors state that there appears to be an increase in positive cells in this mutant.
Specimen 4G: embryonic day 16.5; Cdkn1btm1Mlf/Cdkn1btm1Mlf (more )
Structure Level Pattern Image Note
TS24: adenohypophysis Present 4G The authors state that there appears to be an increase in positive cells in this mutant.
Specimen 4H: embryonic day 16.5; Cdkn1atm1Led/Cdkn1atm1Led, Cdkn1btm1Mlf/Cdkn1btm1Mlf (more )
Structure Level Pattern Image Note
TS24: pituitary gland Present 4H The authors state that there appears to be an increase in positive cells in this mutant.
Specimen 6I: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Present Single cells 6I Positive cells are scattered throughout the lobe.
Specimen 6J: postnatal day 21; Cdkn1atm1Led/Cdkn1atm1Led (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Present Single cells 6J Expression in this mutant is the same as in wild-type.
Specimen 6K: postnatal day 21; Cdkn1btm1Mlf/Cdkn1btm1Mlf (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Present Regionally restricted 6K Expression is in large clusters of cells.
Specimen 6L: postnatal day 21; Cdkn1atm1Led/Cdkn1atm1Led, Cdkn1btm1Mlf/Cdkn1btm1Mlf (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Present Regionally restricted 6L Expression is in large clusters of cells.
Specimen 6M: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis Present Single cells 6M Positive cells are scattered throughout the lobe.
Specimen 6N: postnatal day 21; Cdkn1atm1Led/Cdkn1atm1Led (more )
Structure Level Pattern Image Note
TS28: adenohypophysis Present Single cells 6N Expression in this mutant is the same as in wild-type.
Specimen 6O: postnatal day 21; Cdkn1btm1Mlf/Cdkn1btm1Mlf (more )
Structure Level Pattern Image Note
TS28: adenohypophysis Present Single cells 6O
Specimen 6P: postnatal day 21; Cdkn1atm1Led/Cdkn1atm1Led, Cdkn1btm1Mlf/Cdkn1btm1Mlf (more )
Structure Level Pattern Image Note
TS28: adenohypophysis Present Single cells 6P
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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