Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nfkbiztm1.1Muta
Name:	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; targeted mutation 1.1, Tatsushi Muta
MGI ID:	MGI:5501251
Gene:	Nfkbiz  Location: Chr16:55631740-55659018 bp, - strand  Genetic Position: Chr16, 33.65 cM, cytoband C1.2-C1.3
Alliance:	Nfkbiztm1.1Muta page

Germline Transmission:	Earliest citation of germline transmission: J:194832
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted in intron 4 and an FRT flanked neomycin selection cassette followed by a second loxP site was inserted in intron 7. The selection cassette was excised from properly targeted mice by flp recombinase. (J:194832)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfkbiz Mutation:	33 strains or lines available

Original:	J:194832 Okuma A, et al., Enhanced Apoptosis by Disruption of the STAT3-IkappaB-zeta Signaling Pathway in Epithelial Cells Induces Sjogren's Syndrome-like Autoimmune Disease. Immunity. 2013 Mar 21;38(3):450-60
All:	10 reference(s)