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Gene Expression Data
Assay Details
Assay
Reference: J:85546 Gill SE, et al., A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis. Dev Biol. 2003 Sep 15;261(2):313-23
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5499737
Gene symbol: Fn1
Gene name: fibronectin 1
Antibody: anti-fibronectin
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 6a: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lung mesenchyme Present 6a Expressed in the mesenchymal matrix.
TS23: lung epithelium Present Regionally restricted 6a Expressed in the basement membrane surrounding bronchiole epithelium.

Specimen 6d: embryonic day 15.5; Timp3tm1Rkho/Timp3tm1Rkho (more )
Structure Level Pattern Image Note
TS23: lung epithelium Present Regionally restricted 6d Reduced expression in the basement membranes surrounding the terminal ends and within the cleft regions of developing bronchioles when compared with wild type.
TS23: lung mesenchyme Present 6d Reduced expression compared with wild type.

Specimen 6b: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: lung epithelium Present Regionally restricted 6b Expressed in the basement membrane surrounding bronchiole epithelium.
TS24: lung mesenchyme Present 6b Expressed in the mesenchymal matrix.

Specimen 6e: embryonic day 16.5; Timp3tm1Rkho/Timp3tm1Rkho (more )
Structure Level Pattern Image Note
TS24: lung epithelium Present Regionally restricted 6e Decreased expression in the bronchiole basement membrane.
TS24: lung mesenchyme Present 6e Reduced expression compared with wild type.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory