Palb2tm1.2Dli
Targeted Allele Detail
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Symbol: |
Palb2tm1.2Dli |
Name: |
partner and localizer of BRCA2; targeted mutation 1.2, David M Livingston |
MGI ID: |
MGI:5495930 |
Synonyms: |
Palb2delta |
Gene: |
Palb2 Location: Chr7:121706485-121732203 bp, - strand Genetic Position: Chr7, 65.42 cM
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Alliance: |
Palb2tm1.2Dli page
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Small size and exencephaly in Palb2tm1.2Dli/Palb2tm1.2Dli E10.5 embryos
Show the 1 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2, and a second loxP site, followed by a frt-flanked neomycin resistance (neo) cassette, downstream of exon 3. Cre-mediated recombination removed exon 2, exon 3 and the neomycin reistance cassette. Western blot analysis confirmed the absence of transcript expression in ES cells.
(J:197442)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Palb2 Mutation: |
50 strains or lines available
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Original: |
J:197442 Bowman-Colin C, et al., Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8632-7 |
All: |
1 reference(s) |
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