All Phenotypes Palb2<tm1.2Dli> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Palb2^tm1.2Dli
targeted mutation 1.2, David M Livingston
MGI:5495930

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Palb2^tm1.2Dli/Palb2^tm1.2Dli	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6	MGI:5495975
cx2	Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Palb2^tm1.2Dli/Palb2^tm1.2Dli	involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6	MGI:5495976

Allelic Composition	Palb2^tm1.2Dli/Palb2^tm1.2Dli
Genetic Background	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Palb2^tm1.2Dli mutation (0 available); any Palb2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Small size and exencephaly in Palb2^tm1.2Dli/Palb2^tm1.2Dli E10.5 embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:197442 )

• mice are only recovered up to E12.5

embryonic lethality, incomplete penetrance ( J:197442 )

• fewer than expected mice are recovered up to E12.5

embryo

abnormal placental labyrinth vasculature morphology ( J:197442 )

abnormal vitelline vasculature morphology ( J:197442 )

abnormal embryo development ( J:197442 )

• multiple malformations at E9.5

decreased embryo size ( J:197442 )

• at E10.5

nervous system

exencephaly ( J:197442 )

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:197442 )

abnormal vitelline vasculature morphology ( J:197442 )

growth/size/body

decreased embryo size ( J:197442 )

• at E10.5

Allelic Composition	Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Palb2^tm1.2Dli/Palb2^tm1.2Dli
Genetic Background	involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^tm1Tyj mutation (3 available); any Cdkn1a mutation (60 available)
Palb2^tm1.2Dli mutation (0 available); any Palb2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:197442 )

• lethality observed in Palb2^tm1.2Dli homozygotes is delayed 2 to 3 days

growth/size/body

fetal growth retardation ( J:197442 )

embryo

abnormal embryo development ( J:197442 )

• multiple malformations

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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