About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:48134 Grigoriou M, et al., Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development. 1998 Jun;125(11):2063-74
Assay type: RNA in situ
MGI Accession ID: MGI:5473823
Gene symbol: Lhx6
Gene name: LIM homeobox protein 6
Probe: Lhx6 cDNA4
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen not shown E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch Weak Regionally restricted

Specimen 3A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch Strong Regionally restricted 3A High levels of expression restricted to subdomains of the first branchial arch.

Specimen 3C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Present Regionally restricted 3C Expression in oral (future odontogenic) aspect of mandibular process and part of maxillary process, subdomains bordering the cleft separating the two facial primordia.
TS17: 1st branchial arch maxillary component Present Regionally restricted 3C Expression in oral (future odontogenic) aspect of mandibular process and part of maxillary process, subdomains bordering the cleft separating the two facial primordia.

Specimen 3E: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component mesenchyme derived from neural crest Present 3E
TS17: 1st branchial arch maxillary component mesenchyme derived from neural crest Present 3E
TS17: oral epithelium Absent 3E

Specimen not shown E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: 1st branchial arch Present Regionally restricted Authors report expression in a pattern similar to that of the previous stage.

Specimen 4A: embryonic day 12.5 (more )
Note: Tooth germ stage.
Structure Level Pattern Image Note
TS20: jaw primordium mesenchyme Present Uniform 4A Uniform expression in ectomesenchyme adjoining the oral epithelium.
TS20: oral epithelium Absent 4A

Specimen 4C: embryonic day 13.5 (more )
Note: Tooth bud stage.
Structure Level Pattern Image Note
TS21: lower jaw mesenchyme Present Regionally restricted 4C Expression downregulated in most regions of maxillary and mandibular mesenchyme, but maintained and/or upregulated in mesenchyme adjacent to epithelial thickenings constituting the tooth primordia.
TS21: upper jaw mesenchyme Present Regionally restricted 4C Expression downregulated in most regions of maxillary and mandibular mesenchyme, but maintained and/or upregulated in mesenchyme adjacent to epithelial thickenings constituting the tooth primordia.

Specimen 4E: embryonic day 14.5 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: tooth mesenchyme Strong 4E At subsequent stages, high levels of expression restricted to mesenchymal component of developing tooth.
TS22: tooth epithelium Absent 4E

Specimen 5A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: telencephalon Present Regionally restricted 5A Expression in the medial ganglionic eminence, mainly in the subventricular and submantle zones. No expression in the lateral ganglionic eminence.

Specimen 5B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: medial ganglionic eminence Present Regionally restricted 5B Expression in the medial ganglionic eminence, mainly in the subventricular and submantle zones.
TS21: lateral ganglionic eminence Absent 5B

Specimen 5C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: medial ganglionic eminence Present Regionally restricted 5C Expression in the medial ganglionic eminence, mainly in the subventricular and submantle zones.
TS23: lateral ganglionic eminence Absent 5C

Specimen not shown E11.5 (section): embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: forebrain Present Regionally restricted Domain of expression extends up to a group of cells expressing Fgff8 in the midline of the basal forebrain.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory