Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hdctm1.1(icre)Wwis
Name:	histidine decarboxylase; targeted mutation 1.1, William Wisden
MGI ID:	MGI:5461698
Synonyms:	HDC-Cre
Gene:	Hdc  Location: Chr2:126435587-126461219 bp, - strand  Genetic Position: Chr2, 61.76 cM, cytoband E5-G
Alliance:	Hdctm1.1(icre)Wwis page

Germline Transmission:	Earliest citation of germline transmission: J:188103
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Hdctm1.1(icre)Wwis expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Hdc (MGI:96062)   Mutation details: A targeting vector was generated to insert an improved IRES2i site, a humanized cre open reading frame and an FRT-flanked neo selection cassette into exon 12 of histidine decarboxylase between the stop codon and polyadenylation sequence, by homologous recombination in ES cells. Chimeras were produced by ES cell injection into C57BL/6J blastocysts. The resulting line was bred with Flp deleter mice to remove the neo cassette. (J:188103)

Activity:	Tissue activity of this recombinase allele
Driver:	Hdc (mouse) Summary of all recombinase alleles driven by Hdc. Comparative matrix view of recombinase activities Alliance mouse Hdc gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hdc Mutation:	50 strains or lines available

Original:	J:188103 Zecharia AY, et al., GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J Neurosci. 2012 Sep 19;32(38):13062-75
All:	9 reference(s)