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Calcatm1.1(cre/ERT2)Ptch
Targeted Allele Detail
Summary
Symbol: Calcatm1.1(cre/ERT2)Ptch
Name: calcitonin/calcitonin-related polypeptide, alpha; targeted mutation 1.1, Pao-Tien Chuang
MGI ID: MGI:5460801
Synonyms: CGRPCreER
Gene: Calca  Location: Chr7:114230713-114235592 bp, - strand  Genetic Position: Chr7, 59.99 cM
Alliance: Calcatm1.1(cre/ERT2)Ptch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190366
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Calcatm1.1(cre/ERT2)Ptch expression driven by 1 gene
 
Mutation detailsA cre/ERT2 fusion construct followed by an FRT flanked PGK neo selection cassette was inserted into exon 2 at the ATG translational start site. The selection cassette was subsequently removed by crossing properly targeted mice to mice expressing flp recombinase. (J:190366)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Calca (mouse)
Summary of all recombinase alleles driven by Calca.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Calcatm1.1(cre/ERT2)Ptch
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Calca Mutation:  21 strains or lines available
References
Original:  J:190366 Song H, et al., Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17531-6
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory