About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:75699 Albrecht AN, et al., The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Mech Dev. 2002 Mar;112(1-2):53-67
Assay type: RNA in situ
MGI Accession ID: MGI:5446486
Gene symbol: Hoxd11
Gene name: homeobox D11
Probe: Hoxd11 probe18
Probe preparation: Antisense labelled with P33 RNA
Visualized with: Autoradiography
Results
Specimen 3 Hoxd11 14.5 wt: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb digit mesenchyme Present Regionally restricted 3_Hoxd11 14.5 wt Expression in perichondrium and cartilage; No expression in hypertrophic chondrocytes.
TS22: forelimb phalanx cartilage condensation Present Regionally restricted 3_Hoxd11 14.5 wt Expression in perichondrium and cartilage; No expression in hypertrophic chondrocytes.
TS22: forelimb digit 1 Absent 3_Hoxd11 14.5 wt

Specimen 3 Hoxd11 14.5 spdh/spdh: embryonic day 14.5; Hoxd13spdh/Hoxd13spdh (more )
Structure Level Pattern Image Note
TS22: forelimb digit mesenchyme Strong Regionally restricted 3_Hoxd11 14.5 spdh/spdh Expression in perichondrium and cartilage; No expression in hypertrophic chondrocytes. Authors state that expression was stronger in mutant compared with wildtype.
TS22: forelimb phalanx cartilage condensation Strong Regionally restricted 3_Hoxd11 14.5 spdh/spdh Expression in perichondrium and cartilage; No expression in hypertrophic chondrocytes. Authors state that expression was stronger in mutant compared with wildtype.

Specimen not shown 16.5 wt: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: hand Present Regionally restricted
TS24: forelimb digit 1 Absent

Specimen not shown 16.5 spdh/spdh: embryonic day 16.5; Hoxd13spdh/Hoxd13spdh (more )
Structure Level Pattern Image Note
TS24: hand Present Regionally restricted Authors report similar patterns compared with wild type, but expression was generally stronger.

Specimen not shown Newborn wt: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: hand bone Present Regionally restricted Authors state expression similar to that of Hoxd13, with the exception of digit 1.
TS27: hand connective tissue Present Regionally restricted Authors state expression similar to that of Hoxd13, with the exception of digit 1.
TS27: perichondrium Present Regionally restricted Authors state expression similar to that of Hoxd13, with the exception of digit 1.
TS27: forelimb digit 1 Absent

Specimen not shown Newborn spdh/spdh: postnatal newborn; Hoxd13spdh/Hoxd13spdh (more )
Structure Level Pattern Image Note
TS27: hand bone Present Regionally restricted Authors report similar patterns compared with wild type, but expression was generally stronger.
TS27: hand connective tissue Present Regionally restricted Authors report similar patterns compared with wild type, but expression was generally stronger.
TS27: perichondrium Present Regionally restricted Authors report similar patterns compared with wild type, but expression was generally stronger.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory