Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Eif4e2tm1.1Nso
Name:	eukaryotic translation initiation factor 4E member 2; targeted mutation 1.1, Nahum Sonenberg
MGI ID:	MGI:5444035
Synonyms:	4ehp KO
Gene:	Eif4e2  Location: Chr1:87141636-87168210 bp, + strand  Genetic Position: Chr1, 44.08 cM, cytoband C5
Alliance:	Eif4e2tm1.1Nso page

Germline Transmission:	Earliest citation of germline transmission: J:188802
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 4 and a loxP site was inserted downstream of exon 6 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 4 - 6. Immunoblot analysis confirmed the absence of protein expression in MEFs from homozygous mice. (J:188802)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eif4e2 Mutation:	93 strains or lines available

Original:	J:188802 Morita M, et al., A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol. 2012 Sep;32(17):3585-93
All:	2 reference(s)