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Gene Expression Data
Assay Details
Assay
Reference: J:53540 Kim IS, et al., Regulation of chondrocyte differentiation by Cbfa1. Mech Dev. 1999 Feb;80(2):159-70
Assay type: RNA in situ
MGI Accession ID: MGI:5439290
Gene symbol: Ihh
Gene name: Indian hedgehog
Probe: Ihh probe9
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 3D: embryonic day 17.5; Runx2tm1Mjo/Runx2+ (more )
Structure Level Pattern Image Note
TS25: humerus Present Regionally restricted 3D Expression was detected in the transition zone.
Specimen 6A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: humerus cartilage condensation Present Regionally restricted 6A Expression was detected in chondrocytes of the transition zone. Staining was observed in the central portion of the cartilaginous rod.
Specimen 6B: embryonic day 13.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS21: humerus cartilage condensation Absent 6B
Specimen 6C: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Present 6C
Specimen 6D: embryonic day 14.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Absent 6D
Specimen 6E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: radius cartilage condensation Present 6E
TS22: ulna cartilage condensation Present 6E
Specimen 6F: embryonic day 14.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS22: radius cartilage condensation Present 6F Expression was reduced in the mutant compared to wild type.
TS22: ulna cartilage condensation Present 6F Expression was reduced in the mutant compared to wild type.
Specimen 6G: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb digit cartilage condensation Present 6G
Specimen 6H: embryonic day 14.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS22: forelimb digit cartilage condensation Present 6H Normal expression was detected in the phalanges in the mutant.
Specimen 6I: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: metacarpus cartilage condensation Present 6I
Specimen 6J: embryonic day 14.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS22: metacarpus cartilage condensation Present 6J Normal expression was detected in the metacarpals of the mutant.
Specimen 6K: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: radius Present 6K
TS25: ulna Present 6K
Specimen 6L: embryonic day 17.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS25: radius Present 6L Expression was detected in the radius/ulna as in wild type.
TS25: ulna Present 6L Expression was detected in the radius/ulna as in wild type.
Specimen not shown: embryonic day 17.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS25: forelimb phalanx Absent
Specimen Table 1: embryonic day 14.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Absent
TS22: radius cartilage condensation Weak Expression was significantly less than wild type.
TS22: ulna cartilage condensation Weak Expression was significantly less than wild type.
TS22: forelimb digit cartilage condensation Strong Expression was similar to wild type.
Specimen Table 1: embryonic day 17.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS25: forelimb phalanx Absent
TS25: humerus Absent
TS25: radius Strong Expression was similar to wild type.
TS25: ulna Strong Expression was similar to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory