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Gene Expression Data
Assay Details
Assay
Reference: J:71421 Loes S, et al., Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation. Mech Dev. 2001 Sep;107(1-2):155-7
Assay type: RNA in situ
MGI Accession ID: MGI:5424250
Gene symbol: Slit2
Gene name: slit guidance ligand 2
Probe: Slit2 cDNA4
Probe preparation: Antisense labelled with S35 RNA
Assay notes: The exact developmental stages of the tooth germs were judged from the tissue sections according to morphological criteria.
Results
Specimen 1B1: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: oral region Present Regionally restricted 1B1 Expression is in the jaw mesenchyme partially covering the presumptive dental mesenchyme.
Specimen 1B2: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: oral region Present Regionally restricted 1B2 Expression is in the jaw mesenchyme partially covering the presumptive dental mesenchyme.
Specimen 1B3: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: oral region Present Regionally restricted 1B3 Expression is in the jaw mesenchyme partially covering the presumptive dental mesenchyme.
Specimen 1B4: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: molar mesenchyme Present Regionally restricted 1B4 Expression is around the epithelial bud and in the condensed dental mesenchyme.
TS21: tooth bud Present Regionally restricted 1B4 Expression is around the epithelial bud and in the condensed dental mesenchyme.
Specimen 1B5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: molar dental papilla Strong Regionally restricted 1B5 Absent in dental papilla cells beneath the inner dental epithelium.
TS22: molar mesenchyme Strong Regionally restricted 1B5 Expression is in the dental follicle.
TS22: cap stage tooth Strong Regionally restricted 1B5
Specimen 1B6: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: molar epithelium Present 1B6
TS24: molar dental papilla Present Regionally restricted 1B6 Expression is in cells next to the inner dental epithelium, absent in preodontoblasts.
TS24: bell stage tooth Present Regionally restricted 1B6
Specimen 1B7: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: molar epithelium Present 1B7
TS26: dental papilla Present Regionally restricted 1B7 Expression is in cells next to the inner dental epithelium, absent in preodontoblasts.
TS26: bell stage tooth Present Regionally restricted 1B7
Specimen Not shown: embryonic day 15.5 (more )
Note: Late cap stage of tooth development.
Structure Level Pattern Image Note
TS23: molar enamel organ Strong Regionally restricted Expression is in the middle part.
TS23: molar dental papilla Strong
TS23: enamel knot Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory