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Gt(ROSA)26Sortm6(Acta2-cre)Npa
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm6(Acta2-cre)Npa
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Novartis Pharma AG
MGI ID: MGI:5424002
Synonyms: mR26-alphaSMA-Cre
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm6(Acta2-cre)Npa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184312
Parent Cell Line:  BALB/c-I (ES Cell)
Strain of Origin:  BALB/cJ
Mutation
description
Allele Type:    Targeted (RMCE-ready, Recombinase)
Mutation:    Insertion
 
Gt(ROSA)26Sortm6(Acta2-cre)Npa expression driven by 1 gene
 
Mutation detailsRecombinase-mediated cassette exchange (RMCE) replaced the floxed hygro cassette in Gt(ROSA)26Sortm5Npa with an FRT3 site, Acta2 promoter, cre, neo cassette and FRT site. (J:184312)
Generation of the Gt(ROSA)26Sortm7(Cdh5-cre)Npa and Gt(ROSA)26Sortm6(Acta2-cre)Npa alleles
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Acta2 (species not specified)
Summary of all recombinase alleles driven by Acta2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  935 strains or lines available
References
Original:  J:184312 Tchorz JS, et al., A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters. PLoS One. 2012;7(1):e30011
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory