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Gene Expression Data
Assay Details
Assay
Reference: J:79392 Bai CB, et al., Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development. 2002 Oct;129(20):4753-61
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5320641
Gene symbol: Ptch1
Gene name: patched 1
Reporter: lacZ
Direct Detection
Results
Specimen 4A: embryonic day 8.5; Ptch1tm1Mps/Ptch1+ (more )
Note: This is a 6-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: neural fold Present Regionally restricted 4A Expression is present in the ventral central nervous system.
TS13: somite Present 4A
Specimen 4B: embryonic day 8.5; Gli1tm1Alj/Gli1tm1Alj, Ptch1tm1Mps/Ptch1+ (more )
Note: This is a 6-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: neural fold Present Regionally restricted 4B As in wild type, expression is present in the ventral central nervous system.
TS13: somite Present 4B
Specimen 4C: embryonic day 8.5; Gli2tm1Alj/Gli2tm1Alj, Ptch1tm1Mps/Ptch1+ (more )
Note: This is a 6-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: embryo Present Regionally restricted 4C Expression levels in the mutant are greatly reduced compared to those seen in wild type.
Specimen 4D: embryonic day 8.5; Ptch1tm1Mps/Ptch1tm1Mps (more )
Note: This is a 6-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: embryo Strong 4D There is elevated expression throughout the embryo.
Specimen 4E: embryonic day 8.5; Gli1tm1Alj/Gli1tm1Alj, Ptch1tm1Mps/Ptch1tm1Mps (more )
Note: This is a 6-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: embryo Strong 4E There is elevated expression throughout the embryo.
Specimen 4F: embryonic day 8.5; Gli2tm1Alj/Gli2tm1Alj, Ptch1tm1Mps/Ptch1tm1Mps (more )
Note: This is a 6-8 somite stage embryo.
Structure Level Pattern Image Note
TS13: embryo Present Regionally restricted 4F The overexpression present in the single mutant is reduced in the trunk mesoderm and head of the double mutant.
Specimen 5D: embryonic day 10.5; Ptch1tm1Mps/Ptch1+ (more )
Structure Level Pattern Image Note
TS17: brain Present Regionally restricted 5D Expression is present in the ventral central nervous system.
Specimen 5E: embryonic day 10.5; Gli2tm1Alj/Gli2tm1Alj, Ptch1tm1Mps/Ptch1+ (more )
Structure Level Pattern Image Note
TS17: brain Present Regionally restricted 5E Expression levels in the mutant are severely downregulated.
Specimen 5F: embryonic day 10.5; Gli2tm1Alj/Gli2tm1Alj, Ptch1tm1Mps/Ptch1tm1Mps (more )
Structure Level Pattern Image Note
TS17: brain Present 5F Expression in the brain is upregulated in the double mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory